Obesity has been a problem in the United States for quite some time now. Most
health care practitioners view obesity as a prelude to a variety of conditions
that range from osteoarthritis to cardiovascular disease. An increasingly
serious health issue involves obesity being associated with insulin resistance
and type 2 diabetes. However, it’s not clear if obesity or diabetes develops
first and this question has been a focus of considerable debate and research in
Calories and several other factors contribute to weight gain
A simplistic and sometimes convincing explanation of weight gain involves
looking at calories consumed versus calories expended. The calorie in/calorie
out concept readily explains weight gain when factors that seem to define the
American lifestyle are considered. These factors include consuming large
portions of high fat and high carbohydrate food coupled with a sedentary
lifestyle. An estimated 68% of American adults qualify as overweight or obese
because they eat more calories than they burn. Although this assessment of
weight gain appears logical, there may be several other factors that
contribute to the preponderance of obesity in the United States.
Lack of sleep and BPA
Research has shown that a lack of sufficient sleep (sleep debt) adversely
affects the balance of at least two important hormone-like substances in the
body. Prolonged periods of less than seven hours of sleep each night usually
result in elevated levels of the appetite-stimulating ghrelin and reduced levels
of the satiety-inducing leptin (1, 2). Exposure to excessive levels of BPA (bisphenol
A is a known endocrine disruptor from certain types of plastics) has been shown
to contribute directly to obesity in humans (3). Infections with adenovirus
(there are 52 types of this DNA virus that can invade human cells) cause obesity
in laboratory animals and this may correlate with similar infections in humans
Supplements and weight loss programs
Nutritional supplements and weight loss programs can be safely and
effectively employed in efforts to fight obesity. The following approaches and
ingredients have offered benefit to many who have experienced weight gain and
- Interference with fat absorption from the gastrointestinal tract.
- Phytosterols such as beta-sitosterol.
- Fiber such as
psyllium (soluble fiber).
- Interference with sugar absorption by inhibiting starch breakdown
in the small intestine.
- Amylase inhibitor from the northern white kidney bean.
- Cleansing to facilitate waste and toxin elimination.
- Enhanced breakdown of body fat (thermogenesis).
- Alkaloids such as caffeine and synephrine.
- Accelerated fatty acid oxidation.
- Mitochondrial action of carnitine and acetylcarnitine.
- Glandular support.
Meal replacement provides the proper balance of protein, carbohydrate,
and fat as well as providing the vitamins, minerals, and supplement
ingredients that are conducive to weight loss and important to effective
weight loss programs.
Intestinal flora (gut microbiota) can determine the efficiency of calorie
In my opinion, the most fascinating new research on body weight variation
shows that the intestinal flora (gut microbiota) can determine the efficiency of
calorie extraction from the food that we eat (5). The microbes in the colon
extract energy from the indigestible food passed on from the small intestine.
These microbes ferment food that we cannot digest and they keep most of the
resulting energy for themselves. However, our gut microbiota do share some of
the extracted energy with us but the amount varies from almost nothing to nearly
10% of our daily calories. The relative numbers of certain gut microbes
influence the amount of energy delivered to the host and the subsequent weight
gain liability. There is evidence which suggests that the microbial balance
within the large intestine can be manipulated to cause weight loss. For this
reason, probiotic composition is an attractive target for the development of
weight control measures.
Cornerstones: Diet and Exercise
Keep in mind that diet and exercise are the cornerstones of any successful
weight loss program. I believe that supplements, which include meal replacement
products, can offer meaningful help in weight loss efforts.
loss products and weight loss programs can provide benefits to the vast
majority of consumers who are seeking to lose weight and fight obesity. To reach
your weight loss goals and to keep the weight off, changes in diet, exercise
habits, and lifestyle choices are imperative. And don’t forget determination. If
you have the determination to stick with a proven weight loss program of
NSP supplements together
with diet, exercise, and a healthy lifestyle, you will succeed.
Created by Dr. William J. Keller
1. Sharma, S. Kavuru, M. Sleep and metabolism: an overview. International
Journal of Endocrinology. 2010: 270832. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929498/
Weight and Sleep. Available at
3. Hugo, ER, et al. Bisphenol
A at Environmentally Relevant Doses Inhibits Adiponectin Release from Human
Adipose Tissue Explants and Adipocytes. Environmental Health Perspectives.
2008; 116(12): 1642-1647. Available at:
4. Whigham, LD, et. al. Adipogenic potential of multiple human
adenoviruses in vivo and in vitro in animals. American Journal of
Physiology-Regulatory, Integrative and Comparative Physiology. 2006;
290(1):R190-4. Available at:
RE, et. al. Microbial ecology: human gut microbes associated with obesity.
Nature. 2006; 444(7122): 1022-3. Abstract available at: